PROC Antibody

Product Specifications

Background

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

NCBI Gene ID

5624

Swiss Prot

P04070

Accession Number

P04070

Host

Rabbit

Reactivity

Human

Immunogen

This PROC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-206 amino acids from the Central region of human PROC.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

52 kDa

Fragment

Rabbit Ig

Symbol

PROC

NCBI Official Name

Vitamin K-dependent protein C

NCBI Organism

Homo sapiens

Background Reference 01

Tang, W., et al. Blood (2010) In press :

Background Reference 02

Agapkina, Iu.V., et al. Mol. Biol. (Mosk.) 44 (4) :613-619 (2010)

Background Reference 03

Witt, I., et al. Blood Coagul. Fibrinolysis 5 (4) :651-653 (1994)

Background Reference 04

Zhang, L., et al. Blood 80 (4) :942-952 (1992)

Other Product Names

Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Vitamin K-dependent protein C light chain, Vitamin K-dependent protein C heavy chain, Activation peptide, PROC