SMAD3 Antibody

Product Specifications

Background

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

NCBI Gene ID

4088

Swiss Prot

P84022

Accession Number

P84022

Host

Rabbit

Reactivity

Human

Immunogen

This SMAD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-156 amino acids from the Central region of human SMAD3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Pig, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

48 kDa

Fragment

Rabbit Ig

Symbol

SMAD3

NCBI Official Name

Mothers against decapentaplegic homolog 3

NCBI Organism

Homo sapiens

Background Reference 01

Ge, Q., et al. J. Cell. Physiol. 225 (3) :846-854 (2010)

Background Reference 02

Lee, J., et al. J. Biol. Chem. 285 (34) :26618-26627 (2010)

Background Reference 03

Roder, C., et al. Childs Nerv Syst (2010) In press :

Background Reference 04

Valdes, A.M., et al. Arthritis Rheum. 62 (8) :2347-2352 (2010)

Other Product Names

Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3, SMAD3, MADH3