EIF2S1 Antibody

Product Specifications

Background

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161) . The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]) .

NCBI Gene ID

1965

Swiss Prot

P05198

Accession Number

P05198

Host

Rabbit

Reactivity

Mouse

Immunogen

This EIF2S1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-89 amino acids from the N-terminal region of human EIF2S1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat, Chicken, Yeast, Bovine, Drosophila

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

36 kDa

Fragment

Rabbit Ig

Symbol

EIF2S1

NCBI Official Name

Eukaryotic translation initiation factor 2 subunit 1

NCBI Organism

Homo sapiens

Background Reference 01

Shiota, M., et al. Int. J. Oncol. 36 (6) :1521-1531 (2010)

Background Reference 02

Kulkarni, A.P., et al. Indian J. Biochem. Biophys. 47 (2) :67-74 (2010)

Background Reference 03

Wehner, K.A., et al. Mol. Cell. Biol. 30 (8) :2006-2016 (2010)

Background Reference 04

Backes, S., et al. J. Gen. Virol. 91 (PT 2), 470-482 (2010) :

Other Product Names

Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, EIF2S1, EIF2A