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JPH2 Antibody

Product Specifications

Background

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described.

NCBI Gene ID

57158

Swiss Prot

Q9BR39

Accession Number

Q9BR39

Host

Rabbit

Reactivity

Human

Immunogen

This JPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 614-643 amino acids from the C-terminal region of human JPH2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

74 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

JPH2

NCBI Official Name

Junctophilin-2

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 02

Woo, J.S., et al. Biochem. J. 427 (1) :125-134 (2010)

Background Reference 03

Yamazaki, D., et al. Pharmacol. Ther. 121 (3) :265-272 (2009)

Background Reference 04

Landstrom, A.P., et al. J. Mol. Cell. Cardiol. 42 (6) :1026-1035 (2007)

Other Product Names

Junctophilin-2, JP-2, Junctophilin type 2, JPH2, JP2

Tested Applications

WB

Protein ID

27805486

Physical Properties

Liquid

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