ERV3 Antibody

Product Specifications

Background

The human genome includes many retroelements including the human endogenous retroviruses (HERVs) . ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas. Taken together, the observation of genome conservation, the detection of transcript expression, and the presence of conserved ORFs is circumstantial evidence for a functional role. A functional role is also suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma. [provided by RefSeq].

NCBI Gene ID

2086

Swiss Prot

Q14264

Accession Number

Q14264

Host

Rabbit

Reactivity

Human

Immunogen

This ERV3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids from the C-terminal region of human ERV3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

68 kDa

Fragment

Rabbit Ig

Symbol

ERV3-1

NCBI Official Name

Endogenous retrovirus group 3 member 1 Env polyprotein

NCBI Organism

Homo sapiens

Background Reference 01

Andersson, A.C., et al. J. Virol. 79 (14) :9270-9284 (2005)

Background Reference 02

Herve, C.A., et al. Genomics 83 (5) :940-943 (2004)

Background Reference 03

Blaise, S., et al. Proc. Natl. Acad. Sci. U.S.A. 100 (22) :13013-13018 (2003)

Background Reference 04

De Parseval, N., et al. J. Virol. 77 (19) :10414-10422 (2003)

Other Product Names

Endogenous retrovirus group 3 member 1 Env polyprotein, ERV-3 envelope protein, ERV3 envelope protein, ERV3-1 envelope protein, Envelope polyprotein, HERV-R envelope protein, ERV-R envelope protein, HERV-R_7q212 provirus ancestral Env polyprotein, Surface protein, SU, Transmembrane protein, TM, ERV3-1, ERV3