DPYS Antibody
Product Specifications
Background
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
NCBI Gene ID
1807
Swiss Prot
Q14117
Accession Number
Q14117
Host
Rabbit
Reactivity
Human
Immunogen
This DPYS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-482 amino acids from the C-terminal region of human DPYS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
57 kDa
Fragment
Rabbit Ig
Symbol
DPYS
NCBI Official Name
Dihydropyrimidinase
NCBI Organism
Homo sapiens
Background Reference 01
Kim, H.Y., et al. BMB Rep 43 (8) :547-553 (2010)
Background Reference 02
Van Kuilenburg, A.B., et al. Biochim. Biophys. Acta 1802 (7-8), 639-648 (2010) :
Background Reference 03
Fidlerova, J., et al. Cancer Chemother. Pharmacol. 65 (4) :661-669 (2010)
Background Reference 04
Thomas, H.R., et al. Pharmacogenet. Genomics 18 (1) :25-35 (2008)
Other Product Names
Dihydropyrimidinase, DHP, DHPase, Dihydropyrimidine amidohydrolase, Hydantoinase, DPYS
Tested Applications
WB, IHC-P
Protein ID
3122049
Physical Properties
Liquid
Curated Selection
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