CDKN1B Antibody

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].

This CDKN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-176 amino acids from the C-terminal region of human CDKN1B.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Kajihara, R., et al. Biochem. Biophys. Res. Commun. 401 (3) :350-355 (2010) Kedde, M., et al. Nat. Cell Biol. 12 (10) :1014-1020 (2010) Canbay, E., et al. Anticancer Res. 30 (7) :3093-3098 (2010) Do Nascimento Borges, B., et al. In Vivo 24 (4) :579-582 (2010) Qin, J., et al. Hepatogastroenterology 57 (99-100), 547-553 (2010) :