REPS2 Antibody

Product Specifications

Background

The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

9185

Swiss Prot

Q8NFH8

Accession Number

Q8NFH8

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This REPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the N-terminal region of human REPS2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

72 kDa

Fragment

Rabbit Ig

Symbol

REPS2

NCBI Official Name

RalBP1-associated Eps domain-containing protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Doolan, P., et al. Tumour Biol. 30 (4) :200-209 (2009) Singhal, S.S., et al. J. Biol. Chem. 283 (28) :19714-19729 (2008) Yadav, S., et al. Biochem. Biophys. Res. Commun. 328 (4) :1003-1009 (2005) Oosterhoff, J.K., et al. Int. J. Cancer 113 (4) :561-567 (2005) Penninkhof, F., et al. Oncogene 23 (33) :5607-5615 (2004)