SEC63 Antibody

Product Specifications

Background

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

NCBI Gene ID

11231

Swiss Prot

Q9UGP8

Accession Number

Q9UGP8

Host

Rabbit

Reactivity

Human

Immunogen

This SEC63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 139-168 amino acids from the N-terminal region of human SEC63.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

88 kDa

Fragment

Rabbit Ig

Symbol

SEC63

NCBI Official Name

Translocation protein SEC63 homolog

NCBI Organism

Homo sapiens

Background Reference 01

Waanders, E., et al. Clin. Genet. 78 (1) :47-56 (2010)

Background Reference 02

Van Keimpema, L., et al. Liver Int. (2010) In press :

Background Reference 03

Waanders, E., et al. Histochem. Cell Biol. 129 (3) :301-310 (2008)

Background Reference 04

You, K.T., et al. PLoS Biol. (5), E109 (2007) :

Other Product Names

Translocation protein SEC63 homolog, SEC63, SEC63L

Tested Applications

WB, IHC-P

Protein ID

18203500

Physical Properties

Liquid

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