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RASA1 Antibody

Product Specifications

Background

The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.

NCBI Gene ID

5921

Swiss Prot

P20936

Accession Number

P20936

Host

Rabbit

Reactivity

Human

Immunogen

This RASA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 966-993 amino acids from the C-terminal region of human RASA1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=56-754

Calculated Molecular Weight

116 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

RASA1

NCBI Official Name

Ras GTPase-activating protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Hemerly, J.P., et al. Eur. J. Endocrinol. 163 (5) :747-755 (2010)

Background Reference 02

Wiemels, J.L., et al. Blood Cells Mol. Dis. 45 (3) :186-191 (2010)

Background Reference 03

Bachas, C., et al. Blood 116 (15) :2752-2758 (2010)

Background Reference 04

Oinuma, I., et al. J. Biol. Chem. 285 (36) :28200-28209 (2010)

Other Product Names

Ras GTPase-activating protein 1, GAP, GTPase-activating protein, RasGAP, Ras p21 protein activator, p120GAP, RASA1, GAP, RASA

Tested Applications

WB

Protein ID

121743

Physical Properties

Liquid

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