GCDH Antibody

Product Specifications

Background

The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO (2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.

NCBI Gene ID

2639

Swiss Prot

Q92947

Accession Number

Q92947

Host

Rabbit

Reactivity

Human

Immunogen

This GCDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-365 amino acids from the C-terminal region of human GCDH.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

48 kDa

Fragment

Rabbit Ig

Symbol

GCDH

NCBI Official Name

Glutaryl-CoA dehydrogenase, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 02

Park, J.D., et al. J. Korean Med. Sci. 25 (6) :957-960 (2010)

Background Reference 03

Strauss, K.A., et al. Brain 133 (PT 1), 76-92 (2010) :

Background Reference 04

Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

Other Product Names

Glutaryl-CoA dehydrogenase, mitochondrial, GCD, GCDH

Tested Applications

WB, IHC-P

Protein ID

2492631

Physical Properties

Liquid

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