COPS7A Antibody
Product Specifications
Background
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
NCBI Gene ID
50813
Swiss Prot
Q9UBW8
Accession Number
Q9UBW8
Host
Rabbit
Reactivity
Human
Immunogen
This COPS7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the C-terminal region of human COPS7A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
30 kDa
Fragment
Rabbit Ig
Symbol
COPS7A
NCBI Official Name
COP9 signalosome complex subunit 7a
NCBI Organism
Homo sapiens
Background Reference 01
Matsuoka, S., et al. Science 316 (5828) :1160-1166 (2007)
Background Reference 02
Stelzl, U., et al. Cell 122 (6) :957-968 (2005)
Background Reference 03
Obuse, C., et al. Nat. Cell Biol. 6 (11) :1135-1141 (2004)
Background Reference 04
Wolf, D.A., et al. Nat. Cell Biol. 5 (12) :1029-1033 (2003)
Other Product Names
COP9 signalosome complex subunit 7a, SGN7a, Signalosome subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a, COPS7A, CSN7A, DERP10
Tested Applications
WB, IHC-P
Protein ID
55976618
Physical Properties
Liquid
Curated Selection
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