IREB2 Antibody

Product Specifications

Background

IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

NCBI Gene ID

3658

Swiss Prot

P48200

Accession Number

P48200

Host

Rabbit

Reactivity

Human

Immunogen

This IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the Central region of human IREB2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

105 kDa

Fragment

Rabbit Ig

Symbol

IREB2

NCBI Official Name

Iron-responsive element-binding protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16 (10) :770-777 (2010)

Background Reference 02

Hansen, H.M., et al. Hum. Mol. Genet. 19 (18) :3652-3661 (2010)

Background Reference 03

Cho, M.H., et al. Nat. Genet. 42 (3) :200-202 (2010)

Background Reference 04

Salahudeen, A.A., et al. Science 326 (5953) :722-726 (2009)

Other Product Names

Iron-responsive element-binding protein 2, IRE-BP 2, Iron regulatory protein 2, IRP2, IREB2

Tested Applications

WB, IHC-P, Flow

Protein ID

308153591

Physical Properties

Liquid

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