CLDN2 Antibody

Product Specifications

Background

This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.

NCBI Gene ID

9075

Swiss Prot

P57739

Accession Number

P57739

Host

Rabbit

Reactivity

Human

Immunogen

This CLDN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-227 amino acids from the C-terminal region of human CLDN2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

25 kDa

Fragment

Rabbit Ig

Symbol

CLDN2

NCBI Official Name

Claudin-2

NCBI Organism

Homo sapiens

Background Reference 01

Smith, A.J., et al. J. Acquir. Immune Defic. Syndr. 55 (3) :306-315 (2010)

Background Reference 02

Kojima, F., et al. Oncol. Rep. 23 (4) :927-931 (2010)

Background Reference 03

Szakal, D.N., et al. Virchows Arch. 456 (3) :245-250 (2010)

Background Reference 04

Buchert, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (6) :2628-2633 (2010)

Other Product Names

Claudin-2, SP82, CLDN2

Tested Applications

WB, IHC-P, Flow

Protein ID

12229749

Physical Properties

Liquid

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