CDKN2B Antibody

Product Specifications

Background

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

NCBI Gene ID

1030

Swiss Prot

P42772

Accession Number

P42772

Host

Rabbit

Reactivity

Human

Immunogen

This CDKN2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human CDKN2B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

15 kDa

Fragment

Rabbit Ig

Symbol

CDKN2B

NCBI Official Name

Cyclin-dependent kinase 4 inhibitor B

NCBI Organism

Homo sapiens

Background Reference 01

Camacho, C.V., et al. Carcinogenesis 31 (10) :1889-1896 (2010)

Background Reference 02

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 03

Pechlivanis, S., et al. Arterioscler. Thromb. Vasc. Biol. 30 (9) :1867-1872 (2010)

Background Reference 04

Heni, M., et al. Diabetes (2010) In press :

Other Product Names

Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2, MTS-2, p14-INK4b, p15-INK4b, p15INK4B, CDKN2B, MTS2

Tested Applications

WB, IHC-P, IF, Flow

Protein ID

1168869

Physical Properties

Liquid

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