PREX1 Antibody

Product Specifications

Background

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs) . It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.

NCBI Gene ID

57580

Swiss Prot

Q8TCU6

Accession Number

Q8TCU6

Host

Rabbit

Reactivity

Human

Immunogen

This PREX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1134-1163 amino acids from the C-terminal region of human PREX1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

186 kDa

Fragment

Rabbit Ig

Symbol

PREX1

NCBI Official Name

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

NCBI Organism

Homo sapiens

Background Reference 01

Lewis, J.P., et al. Genomics 96 (4) :211-219 (2010)

Background Reference 02

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 03

Nie, B., et al. Cell. Signal. 22 (5) :770-782 (2010)

Background Reference 04

Carretero-Ortega, J., et al. Mol. Pharmacol. 77 (3) :435-442 (2010)

Other Product Names

Phosphatidylinositol 3,5-trisphosphate-dependent Rac exchanger 1 protein, P-Rex1, PtdIns (3,5) -dependent Rac exchanger 1, PREX1, KIAA1415

Tested Applications

WB, IHC-P, Flow

Protein ID

148886999

Physical Properties

Liquid

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