PC Antibody

Product Specifications

Background

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq].

NCBI Gene ID

5091

Swiss Prot

P11498

Accession Number

P11498

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This PC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the N-terminal region of human PC.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

130 kDa

Fragment

Rabbit Ig

Symbol

NCBI Official Name

Pyruvate carboxylase, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

MacDonald, M.J., et al. Diabetologia 52 (6) :1087-1091 (2009)

Background Reference 02

Monnot, S., et al. Hum. Mutat. 30 (5) :734-740 (2009)

Background Reference 03

Wang, D., et al. Mol. Genet. Metab. 95 (1-2), 31-38 (2008) :

Background Reference 04

Vora, S., et al. Natl MedIndia 21 (3) :116-119 (2008)

Other Product Names

Pyruvate carboxylase, mitochondrial, Pyruvic carboxylase, PCB, PC

Tested Applications

WB, IHC-P

Protein ID

1709947

Physical Properties

Liquid

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