PDC Antibody
Product Specifications
Background
This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.
NCBI Gene ID
5132
Swiss Prot
P20941
Accession Number
P20941
Host
Rabbit
Reactivity
Human
Immunogen
This PDC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-88 amino acids from the Central region of human PDC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
28 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PDC
NCBI Official Name
Phosducin
NCBI Organism
Homo sapiens
Background Reference 01
Beetz, N., et al. J. Clin. Invest. 119 (12) :3597-3612 (2009)
Background Reference 02
Klenk, C., et al. J. Biol. Chem. 281 (13) :8357-8364 (2006)
Background Reference 03
Nishiguchi, K.M., et al. Mol. Vis. 10, 62-64 (2004) :
Background Reference 04
Margulis, A., et al. Mol. Vis. 8, 477-482 (2002) :
Other Product Names
Phosducin, PHD, 33 kDa phototransducing protein, Protein MEKA, PDC
Tested Applications
WB
Protein ID
130134
Physical Properties
Liquid
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