UNC84B Antibody

Product Specifications

Background

SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM) . The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]) .[supplied by OMIM].

NCBI Gene ID

25777

Swiss Prot

Q9UH99

Accession Number

Q9UH99

Host

Rabbit

Reactivity

Human

Immunogen

This UNC84B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-265 amino acids from the Central region of human UNC84B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

80 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SUN2

NCBI Official Name

SUN domain-containing protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Turgay, Y., et al. EMBO J. 29 (14) :2262-2275 (2010)

Background Reference 02

Haque, F., et al. J. Biol. Chem. 285 (5) :3487-3498 (2010)

Background Reference 03

Stewart-Hutchinson, P.J., et al. Exp. Cell Res. 314 (8) :1892-1905 (2008)

Background Reference 04

Cerhan, J.R., et al. Blood 110 (13) :4455-4463 (2007)

Other Product Names

SUN domain-containing protein 2, Protein unc-84 homolog B, Rab5-interacting protein, Rab5IP, Sad1/unc-84 protein-like 2, SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B