IGSF8 Antibody
Product Specifications
Background
IGSF8 may play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
NCBI Gene ID
93185
Swiss Prot
Q969P0
Accession Number
Q969P0
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This IGSF8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 amino acids from the Central region of human IGSF8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
65 kDa
Fragment
Rabbit Ig
Symbol
IGSF8
NCBI Official Name
Immunoglobulin superfamily member 8
NCBI Organism
Homo sapiens
Background Reference 01
Kolesnikova, T.V., et al. Neoplasia 11 (1) :77-86 (2009)
Background Reference 02
Rocha-Perugini, V., et al. PLoS ONE (4), E1866 (2008) :
Background Reference 03
Kettner, S., et al. Mol. Cell. Biol. 27 (21) :7718-7726 (2007)
Background Reference 04
Sala-Valdes, M., et al. J. Biol. Chem. 281 (28) :19665-19675 (2006)
Other Product Names
Immunoglobulin superfamily member 8, IgSF8, CD81 partner 3, Glu-Trp-Ile EWI motif-containing protein 2, EWI-2, Keratinocytes-associated transmembrane protein 4, KCT-4, LIR-D1, Prostaglandin regulatory-like protein, PGRL, CD316, IGSF8, CD81P3, EWI2, KCT4
Tested Applications
WB, IHC-P
Protein ID
74762642
Physical Properties
Liquid
Curated Selection
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