ARHB Antibody

Product Specifications

Background

ARHB mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.

NCBI Gene ID

388

Swiss Prot

P62745

Accession Number

P62745

Host

Rabbit

Reactivity

Human

Immunogen

This ARHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-137 amino acids from the Central region of human ARHB.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

22 kDa

Fragment

Rabbit Ig

Symbol

RHOB

NCBI Official Name

Rho-related GTP-binding protein RhoB

NCBI Organism

Homo sapiens

Background Reference 01

Adly, M.A., et al. J. Cutan. Pathol. 37 (7) :751-757 (2010)

Background Reference 02

Connolly, E.C., et al. Mol. Cancer Res. 8 (5) :691-700 (2010)

Background Reference 03

Zintzaras, E., et al. Am. J. Epidemiol. 171 (8) :851-858 (2010)

Background Reference 04

Kim, C.H., et al. Biochem. Biophys. Res. Commun. 391 (2) :1182-1186 (2010)

Other Product Names

Rho-related GTP-binding protein RhoB, Rho cDNA clone 6, h6, RHOB, ARH6, ARHB

Tested Applications

WB, IHC-P

Protein ID

51338601

Physical Properties

Liquid

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