RBL2 Antibody

Product Specifications

Background

RBL2 is a key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. RBL2 may act as a tumor suppressor.

NCBI Gene ID

5934

Swiss Prot

Q08999

Accession Number

Q08999

Host

Rabbit

Reactivity

Human

Immunogen

This RBL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-194 amino acids from the N-terminal region of human RBL2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

128 kDa

Fragment

Rabbit Ig

Symbol

RBL2

NCBI Official Name

Retinoblastoma-like protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Schaffer, B.E., et al. Cancer Res. 70 (10) :3877-3883 (2010)

Background Reference 02

Barrow-Laing, L., et al. Virology 400 (2) :233-239 (2010)

Background Reference 03

Lu, F., et al. J. Virol. 84 (6) :2697-2706 (2010)

Background Reference 04

Jowett, J.B., et al. Diabetes 59 (3) :726-732 (2010)

Other Product Names

Retinoblastoma-like protein 2, 130 kDa retinoblastoma-associated protein, p130, Retinoblastoma-related protein 2, RBR-2, pRb2, RBL2, RB2

Tested Applications

WB, Flow

Protein ID

116242746

Physical Properties

Liquid

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