DOK3 Antibody
Product Specifications
Background
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function (By similarity) .
NCBI Gene ID
79930
Swiss Prot
Q7L591
Accession Number
Q7L591
Host
Rabbit
Reactivity
Human
Immunogen
This DOK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-321 amino acids from the C-terminal region of human DOK3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
53 kDa
Fragment
Rabbit Ig
Symbol
DOK3
NCBI Official Name
Docking protein 3
NCBI Organism
Homo sapiens
Background Reference 01
Berger, A.H., et al. Nat. Genet. 42 (3) :216-223 (2010)
Background Reference 02
Senis, Y.A., et al. J. Thromb. Haemost. 7 (10) :1718-1726 (2009)
Background Reference 03
Honma, M., et al. Genes Cells 11 (2) :143-151 (2006)
Background Reference 04
Robson, J.D., et al. Mol. Cell. Biol. 24 (6) :2332-2343 (2004)
Other Product Names
Docking protein 3, Downstream of tyrosine kinase 3, DOK3
Tested Applications
WB, IHC-P
Protein ID
84029599
Physical Properties
Liquid
Curated Selection
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