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GDF5 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.

NCBI Gene ID

8200

Swiss Prot

P43026

Accession Number

P43026

Host

Rabbit

Reactivity

Human

Immunogen

This GDF5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-371 amino acids from the C-terminal region of human GDF5.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=56-193

Calculated Molecular Weight

55 kDa

Fragment

Rabbit Ig

Symbol

GDF5

NCBI Official Name

Growth/differentiation factor 5

NCBI Organism

Homo sapiens

Background Reference 01

Posthumus, M., et al. Rheumatology (Oxford) 49 (11) :2090-2097 (2010)

Background Reference 02

Rouault, K., et al. Osteoarthr. Cartil. 18 (9) :1144-1149 (2010)

Background Reference 03

Zintzaras, E., et al. Am. J. Epidemiol. 171 (8) :851-858 (2010)

Background Reference 04

Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

Other Product Names

Growth/differentiation factor 5, GDF-5, Bone morphogenetic protein 14, BMP-14, Cartilage-derived morphogenetic protein 1, CDMP-1, Lipopolysaccharide-associated protein 4, LAP-4, LPS-associated protein 4, Radotermin, GDF5, BMP14, CDMP1

Tested Applications

WB, IHC-P

Protein ID

20141384

Physical Properties

Liquid

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