TRADD Antibody

Product Specifications

Background

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq].

NCBI Gene ID

8717

Swiss Prot

Q15628

Accession Number

Q15628

Host

Rabbit

Reactivity

Human

Immunogen

This TRADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-151 amino acids from the Central region of human TRADD.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

34 kDa

Fragment

Rabbit Ig

Symbol

TRADD

NCBI Official Name

Tumor necrosis factor receptor type 1-associated DEATH domain protein

NCBI Organism

Homo sapiens

Background Reference 01

Pointon, J.J., et al. Ann. Rheum. Dis. 69 (6) :1243-1246 (2010)

Background Reference 02

Hosgood, H.D. III, et al. Occup Environ Med 66 (12) :848-853 (2009)

Background Reference 03

Yerges, L.M., et al. J. Bone Miner. Res. 24 (12) :2039-2049 (2009)

Background Reference 04

Liang, X.S., et al. Br. J. Haematol. 146 (4) :418-423 (2009)

Other Product Names

Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain, TRADD