UGT8 antibody

Product Specifications

Background

Galactocerebrosides are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system and are also present in small amounts in kidney. The key enzymatic step in the biosynthesis of galactocerebrosides consists of the transfer of galactose to ceramide catalyzed by UDP-galactose ceramide galactosyltransferase (CGT, EC 2.4.1.45) . The enzyme encoded by the CGT gene is the first involved in complex lipid biosynthesis in the myelinating oligodendrocyte.[supplied by OMIM].

NCBI Gene ID

7368

Swiss Prot

Q16880

Accession Number

Q16880

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This UGT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-393 amino acids from the Central region of human UGT8.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

61 kDa

Fragment

Rabbit Ig

Symbol

UGT8

NCBI Official Name

2-hydroxyacylsphingosine 1-beta-galactosyltransferase

NCBI Organism

Homo sapiens

Background Reference 01

Dziecedil Giel, P., et al. Br. J. Cancer 103 (4) :524-531 (2010)

Background Reference 02

Kalsi, G., et al. Hum. Mol. Genet. 19 (12) :2497-2506 (2010)

Background Reference 03

Ross, C.J., et al. Nat. Genet. 41 (12) :1345-1349 (2009)

Background Reference 04

Ruckhaberle, E., et al. J. Cancer Res. Clin. Oncol. 135 (8) :1005-1013 (2009)

Other Product Names

2-hydroxyacylsphingosine 1-beta-galactosyltransferase, Ceramide UDP-galactosyltransferase, Cerebroside synthase, UDP-galactose-ceramide galactosyltransferase, UGT8, CGT, UGT4