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MSH2 Antibody

Product Specifications

Background

MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. [provided by RefSeq].

NCBI Gene ID

4436

Swiss Prot

P43246

Accession Number

P43246

Host

Rabbit

Reactivity

Human

Immunogen

This MSH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 637-665 amino acids from the Central region of human MSH2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=55-920

Calculated Molecular Weight

105 kDa

Fragment

Rabbit Ig

Symbol

MSH2

NCBI Official Name

DNA mismatch repair protein Msh2

NCBI Organism

Homo sapiens

Background Reference 01

Kim, M., et al. Cancer Sci. 101 (11) :2436-2442 (2010)

Background Reference 02

Mangoni, M., et al. Int. J. Radiat. Oncol. Biol. Phys. (2010) In press :

Background Reference 03

Srivastava, K., et al. Cancer 116 (13) :3160-3169 (2010)

Background Reference 04

Van der Post, R.S., et al. J. Med. Genet. 47 (7) :464-470 (2010)

Other Product Names

DNA mismatch repair protein Msh2, hMSH2, MutS protein homolog 2, MSH2

Tested Applications

WB, IF, Flow

Protein ID

1171032

Physical Properties

Liquid

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