GUCY2D Antibody

Product Specifications

Background

This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq].

NCBI Gene ID

3000

Swiss Prot

Q02846

Accession Number

Q02846

Host

Rabbit

Reactivity

Human, Rat

Immunogen

This GUCY2D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 540-570 amino acids from the Central region of human GUCY2D.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

120 kDa

Fragment

Rabbit Ig

Symbol

GUCY2D

NCBI Official Name

Retinal guanylyl cyclase 1

NCBI Organism

Homo sapiens

Background Reference 01

Silva, L.K., et al. Eur. J. Hum. Genet. 18 (11) :1221-1227 (2010)

Background Reference 02

Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)

Background Reference 03

Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34 (5) :800-812 (2010)

Background Reference 04

Pasadhika, S., et al. Invest. Ophthalmol. Vis. Sci. 51 (5) :2608-2614 (2010)

Other Product Names

Retinal guanylyl cyclase 1, RETGC-1, Guanylate cyclase 2D, retinal, Rod outer segment membrane guanylate cyclase, ROS-GC, GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1