COPE Antibody

Product Specifications

Background

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.

NCBI Gene ID

11316

Swiss Prot

O14579

Accession Number

O14579

Host

Rabbit

Reactivity

Human

Immunogen

This COPE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-300 amino acids from the C-terminal region of human COPE.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken, Hamster, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

34 kDa

Fragment

Rabbit Ig

Symbol

COPE

NCBI Official Name

Coatomer subunit epsilon

NCBI Organism

Homo sapiens

Background Reference 01

Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

Background Reference 02

Morikawa, R.K., et al. J. Biol. Chem. 284 (39) :26620-26630 (2009)

Background Reference 03

Maruyama, S., et al. Mol. Cell. Biochem. 307 (1-2), 73-82 (2008) :

Background Reference 04

Goryachev, A.B., et al. PLoS Comput. Biol. (12), E172 (2006) :

Other Product Names

Coatomer subunit epsilon, Epsilon-coat protein, Epsilon-COP, COPE

Tested Applications

WB, IHC-P, IF

Physical Properties

Liquid

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