NCOR1 Antibody

Product Specifications

Background

NCOR1 mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. The gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.

NCBI Gene ID

9611

Swiss Prot

O75376

Accession Number

O75376

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This NCOR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-47 amino acids from the N-terminal region of human NCOR1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

270 kDa

Fragment

Rabbit Ig

Symbol

NCOR1

NCBI Official Name

Nuclear receptor corepressor 1

NCBI Organism

Homo sapiens

Background Reference 01

Tai, H.H., et al., Biochem. Biophys. Res. Commun. 308 (1) :170-176 (2003) .

Background Reference 02

Ishizuka, T., et al., Mol. Cell. Biol. 23 (15) :5122-5131 (2003) .

Background Reference 03

Loinder, K., et al., J. Steroid Biochem. Mol. Biol. 84 (1) :15-21 (2003) .

Background Reference 04

Wang, S., et al., Oncogene 21 (55) :8388-8396 (2002) .

Other Product Names

Nuclear receptor corepressor 1, N-CoR, N-CoR1, NCOR1, KIAA1047

Tested Applications

WB, IHC-P, IF

Physical Properties

Liquid

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