LARS Antibody
Product Specifications
Background
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA (Leu) . It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.
NCBI Gene ID
51520
Swiss Prot
Q9P2J5
Accession Number
Q9P2J5
Host
Rabbit
Reactivity
Mouse
Immunogen
This LARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-205 amino acids from the N-terminal region of human LARS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
134 kDa
Fragment
Rabbit Ig
Symbol
LARS
NCBI Official Name
Leucine--tRNA ligase, cytoplasmic
NCBI Organism
Homo sapiens
Background Reference 01
Pang, Y.L., et al. Biochemistry 48 (38) :8958-8964 (2009)
Background Reference 02
Seiradake, E., et al. J. Mol. Biol. 390 (2) :196-207 (2009)
Background Reference 03
Shin, S.H., et al. Exp. Mol. Med. 40 (2) :229-236 (2008)
Background Reference 04
Maeso, E., et al. Neuromuscul. Disord. 17 (5) :415-418 (2007)
Other Product Names
Leucine--tRNA ligase, cytoplasmic, Leucyl-tRNA synthetase, LeuRS, LARS, KIAA1352
Tested Applications
WB, Flow
Protein ID
48428689
Physical Properties
Liquid
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