KARS Antibody
Product Specifications
Background
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
3735
Swiss Prot
Q15046
Accession Number
Q15046
Host
Rabbit
Reactivity
Human
Immunogen
This KARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 amino acids from the N-terminal region of human KARS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
68 kDa
Fragment
Rabbit Ig
Symbol
KARS
NCBI Official Name
Lysine--tRNA ligase
NCBI Organism
Homo sapiens
Background Reference 01
McLaughlin, H.M., et al. Am. J. Hum. Genet. 87 (4) :560-566 (2010)
Background Reference 02
Kepp, O., et al. Cell Cycle 9 (15) :3072-3077 (2010)
Background Reference 03
Segat, L., et al. Vaccine 28 (10) :2201-2206 (2010)
Background Reference 04
Dastani, Z., et al. Eur. J. Hum. Genet. 18 (3) :342-347 (2010)
Other Product Names
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS, KARS, KIAA0070
Tested Applications
WB, Flow
Protein ID
20178333
Physical Properties
Liquid
Curated Selection
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