ERCC8 Antibody

Product Specifications

Background

This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS) . CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.

NCBI Gene ID

1161

Swiss Prot

Q13216

Accession Number

Q13216

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This ERCC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-238 amino acids from the Central region of human ERCC8.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

44 kDa

Fragment

Rabbit Ig

Symbol

ERCC8

NCBI Official Name

DNA excision repair protein ERCC-8

NCBI Organism

Homo sapiens

Background Reference 01

Briggs, F.B., et al. Am. J. Epidemiol. 172 (2) :217-224 (2010)

Background Reference 02

Guillem, V.M., et al. Am. J. Hematol. 85 (7) :482-486 (2010)

Background Reference 03

Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :

Background Reference 04

Kamenisch, Y., et al. J. Exp. Med. 207 (2) :379-390 (2010)

Other Product Names

DNA excision repair protein ERCC-8, Cockayne syndrome WD repeat protein CSA, ERCC8, CKN1, CSA

Tested Applications

WB, IHC-P

Protein ID

3121917

Physical Properties

Liquid

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