KAT1 Antibody

Product Specifications

Background

Histone acetylation, particularly of histone H4, has been proposed to play an important role in replication-dependent nucleosome assembly. The HAT1 protein contains D, A, and B motifs, which are present in many N-acetyltransferases, including those that acetylate substrates other than histones. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46. The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. HAT1 may play a role in telomeric silencing.

NCBI Gene ID

8520

Swiss Prot

O14929

Accession Number

O14929

Host

Rabbit

Reactivity

Human

Immunogen

This KAT1 (HAT1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-58 amino acids from the N-terminal region of human KAT1 (HAT1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

50 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

HAT1

NCBI Official Name

Histone acetyltransferase type B catalytic subunit

NCBI Organism

Homo sapiens

Background Reference 01

Gronroos, E., et al., Mol. Cell 10 (3) :483-493 (2002) .

Background Reference 02

Makowski, A.M., et al., J. Biol. Chem. 276 (47) :43499-43502 (2001) .

Background Reference 03

Cheung, P., et al., Mol. Cell 5 (6) :905-915 (2000) .

Background Reference 04

Verreault, A., et al., Curr. Biol. 8 (2) :96-108 (1998) .

Other Product Names

Histone acetyltransferase type B catalytic subunit, Histone acetyltransferase 1, HAT1, KAT1

Tested Applications

Physical Properties

Liquid

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