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IBTK Antibody

Product Specifications

Background

The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.

NCBI Gene ID

25998

Swiss Prot

Q9P2D0

Accession Number

Q9P2D0

Host

Rabbit

Reactivity

Human

Immunogen

This IBTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-613 amino acids from the Central region of human IBTK.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

151 kDa

Fragment

Rabbit Ig

Symbol

IBTK

NCBI Official Name

Inhibitor of Bruton tyrosine kinase

NCBI Organism

Homo sapiens

Background Reference 01

Fiume, G., et al. Comput Biol Chem 33 (6) :434-439 (2009)

Background Reference 02

Spatuzza, C., et al. Nucleic Acids Res. 36 (13) :4402-4416 (2008)

Background Reference 03

Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

Background Reference 04

Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

Other Product Names

Inhibitor of Bruton tyrosine kinase, IBtk, IBTK, BTKI, KIAA1417

Tested Applications

WB, IHC-P, Flow

Protein ID

134034141

Physical Properties

Liquid

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