COL18A1 Antibody
Product Specifications
Background
COL18A1 is the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure.
NCBI Gene ID
80781
Swiss Prot
P39060
Accession Number
P39060
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This COL18A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1311-1339 amino acids from the Central region of human COL18A1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
178 kDa
Fragment
Rabbit Ig
Symbol
COL18A1
NCBI Official Name
Collagen alpha-1 (XVIII) chain
NCBI Organism
Homo sapiens
Background Reference 01
Hamano, Y., et al. J. Am. Soc. Nephrol. 21 (9) :1445-1455 (2010)
Background Reference 02
Roberts, K.E., et al. Gastroenterology 139 (1) :130-139 (2010)
Background Reference 03
Lee, K.S., et al. Tumour Biol. 31 (3) :165-170 (2010)
Background Reference 04
Faye, C., et al. Biochem. J. 427 (3) :467-475 (2010)
Other Product Names
Collagen alpha-1 (XVIII) chain, Endostatin, COL18A1
Tested Applications
WB, IHC-P
Protein ID
215274264
Physical Properties
Liquid
Curated Selection
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