FOLR1 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.

NCBI Gene ID

2348

Swiss Prot

P15328

Accession Number

P15328

Host

Rabbit

Reactivity

Human

Immunogen

This FOLR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-68 amino acids from the N-terminal region of human FOLR1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

30 kDa

Fragment

Rabbit Ig

Symbol

FOLR1

NCBI Official Name

Folate receptor alpha

NCBI Organism

Homo sapiens

Background Reference 01

Sivakumaran, S., et al. J. Steroid Biochem. Mol. Biol. 122 (5) :333-340 (2010)

Background Reference 02

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 03

O'Byrne, M.R., et al. Birth Defects Res. PartClin. Mol. Teratol. 88 (8) :689-694 (2010)

Background Reference 04

Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

Other Product Names

Folate receptor alpha, FR-alpha, Adult folate-binding protein, FBP, Folate receptor 1, Folate receptor, adult, KB cells FBP, Ovarian tumor-associated antigen MOv18, FOLR1, FOLR