IL12_2 Antibody

Product Specifications

Background

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.

NCBI Gene ID

3595

Swiss Prot

Q99665

Accession Number

Q99665

Host

Rabbit

Reactivity

Human

Immunogen

This IL12_2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 756-783 amino acids from the C-terminal region of human IL12_2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

97 kDa

Fragment

Rabbit Ig

Symbol

IL12RB2

NCBI Official Name

Interleukin-12 receptor subunit beta-2

NCBI Organism

Homo sapiens

Background Reference 01

Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :

Background Reference 02

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 03

Liu, X., et al. Nat. Genet. 42 (8) :658-660 (2010)

Background Reference 04

Mizuki, N., et al. Nat. Genet. 42 (8) :703-706 (2010)

Other Product Names

Interleukin-12 receptor subunit beta-2, IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, IL-12RB2, IL12RB2

Tested Applications

WB, IHC-P, Flow

Protein ID

12229836

Physical Properties

Liquid

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