APCS Antibody
Product Specifications
Background
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.
NCBI Gene ID
325
Swiss Prot
P02743
Accession Number
P02743
Host
Rabbit
Reactivity
Human
Immunogen
This APCS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-178 amino acids from the C-terminal region of human APCS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
25 kDa
Fragment
Rabbit Ig
Symbol
APCS
NCBI Official Name
Serum amyloid P-component
NCBI Organism
Homo sapiens
Background Reference 01
Song, Z., et al. Atherosclerosis 211 (1) :90-95 (2010)
Background Reference 02
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 03
McGeachie, M., et al. Circulation 120 (24) :2448-2454 (2009)
Background Reference 04
Lu, J., et al. Nature 456 (7224) :989-992 (2008)
Other Product Names
Serum amyloid P-component, SAP, 95S alpha-1-glycoprotein, Serum amyloid P-component (1-203), APCS, PTX2
Tested Applications
WB, IHC-P
Protein ID
730704
Physical Properties
Liquid
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