ACF Antibody

Product Specifications

Background

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events.

NCBI Gene ID

29974

Swiss Prot

Q9NQ94

Accession Number

Q9NQ94

Host

Rabbit

Reactivity

Human

Immunogen

This ACF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-423 amino acids from the C-terminal region of human ACF.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

65 kDa

Fragment

Rabbit Ig

Symbol

A1CF

NCBI Official Name

APOBEC1 complementation factor

NCBI Organism

Homo sapiens

Background Reference 01

Galloway, C.A., et al. Biochem. Biophys. Res. Commun. 391 (1) :659-663 (2010)

Background Reference 02

Blanc, V., et al. Mol. Cell. Biol. 25 (16) :7260-7269 (2005)

Background Reference 03

Deloukas, P., et al. Nature 429 (6990) :375-381 (2004)

Background Reference 04

Xie, K., et al. Proc. Natl. Acad. Sci. U.S.A. 101 (21) :8114-8119 (2004)

Other Product Names

APOBEC1 complementation factor, APOBEC1-stimulating protein, A1CF, ACF, ASP {ECO:0000312|EMBL:CAB947541}

Tested Applications

WB, IHC-P, Flow

Protein ID

74761651

Physical Properties

Liquid

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