CES2 Antibody

Product Specifications

Background

CES2 is a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance.

NCBI Gene ID

8824

Swiss Prot

O00748

Accession Number

O00748

Host

Rabbit

Reactivity

Human

Immunogen

This CES2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-369 amino acids from the Central region of human CES2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

62 kDa

Fragment

Rabbit Ig

Symbol

CES2

NCBI Official Name

Cocaine esterase

NCBI Organism

Homo sapiens

Background Reference 01

Holmes, R.S., et al. Mamm. Genome 21 (9-10), 427-441 (2010) Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010) Howard, T.D., et al. Environ. Health Perspect. 118 (10) :1395-1399 (2010) Hatfield, M.J., et al. Br. J. Pharmacol. 160 (8) :1916-1928 (2010) Holmes, R.S., et al. Genetica 138 (7) :695-708 (2010)