LILRA2 Antibody

Product Specifications

Background

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811) . LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.

NCBI Gene ID

11027

Swiss Prot

Q8N149

Accession Number

Q8N149

Host

Rabbit

Reactivity

Human

Immunogen

This LILRA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-81 amino acids from the Central region of human LILRA2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

53 kDa

Fragment

Rabbit Ig

Symbol

LILRA2

NCBI Official Name

Leukocyte immunoglobulin-like receptor subfamily A member 2

NCBI Organism

Homo sapiens

Background Reference 01

Mosbruger, T.L., et al. J. Infect. Dis. 201 (9) :1371-1380 (2010)

Background Reference 02

Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

Background Reference 03

Jones, D.C., et al. Eur. J. Immunol. 39 (11) :3195-3206 (2009)

Background Reference 04

Chen, Y., et al. J. Mol. Biol. 386 (3) :841-853 (2009)

Other Product Names

Leukocyte immunoglobulin-like receptor subfamily A member 2, CD85 antigen-like family member H, Immunoglobulin-like transcript 1, ILT-1, Leukocyte immunoglobulin-like receptor 7, LIR-7, CD85h, LILRA2, ILT1, LIR7