SAR1B Antibody

Product Specifications

Background

The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD) . Two transcript variants encoding the same protein have been found for this gene.

NCBI Gene ID

51128

Swiss Prot

Q9Y6B6

Accession Number

Q9Y6B6

Host

Rabbit

Reactivity

Human

Immunogen

This SAR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-116 amino acids from the Central region of human SAR1B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Hamster, Mouse, Pig, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

22 kDa

Fragment

Rabbit Ig

Symbol

SAR1B

NCBI Official Name

GTP-binding protein SAR1b

NCBI Organism

Homo sapiens

Background Reference 01

Cefalu, A.B., et al. Metab. Clin. Exp. 59 (4) :463-467 (2010)

Background Reference 02

Silvain, M., et al. Clin. Genet. 74 (6) :546-552 (2008)

Background Reference 03

Charcosset, M., et al. Mol. Genet. Metab. 93 (1) :74-84 (2008)

Background Reference 04

Jardim, D.L., et al. J. Biochem. Mol. Biol. 38 (3) :328-333 (2005)

Other Product Names

GTP-binding protein SAR1b, GTP-binding protein B, GTBPB, SAR1B, SARA2, SARB

Tested Applications

WB, IHC-P, Flow

Protein ID

14285769

Physical Properties

Liquid

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