TSHR beta chain Antibody [TSHRB/1405]
Product Specifications
Background
Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.
NCBI Gene ID
7253
Swiss Prot
P16473
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human TSH Receptor beta chain protein was used as the immunogen for this TSHR antibody.
Clonality
Monoclonal
Clone
TSHRB/1405
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Cancer, Signal Transduction, Immunology
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=33-791
Fragment
IgG2a
Symbol
TSHR
NCBI Official Name
Thyroid stimulating hormone receptor
NCBI Organism
Homo sapiens
Other Product Names
TSHR, LGR3, MGC75129, hTSHR-I, CHNG1
Tested Applications
WB, Flow, IF, IHC-P
Physical Properties
Liquid
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