CD45RA Antibody [PTPRC/1131]
Product Specifications
Background
CD45RA is an isoform of the human leukocyte common antigen (CD45) . Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve) .
NCBI Gene ID
5788
Swiss Prot
P08575
Host
Mouse
Reactivity
Human
Immunogen
Stimulated human leukocytes were used as immunogen for this CD45RA antibody.
Clonality
Monoclonal
Clone
PTPRC/1131
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Neuroscience, Signal Transduction
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=33-293
Fragment
IgG1, kappa
Symbol
PTPRC
NCBI Official Name
Protein tyrosine phosphatase, receptor type, C
NCBI Organism
Homo sapiens
Other Product Names
Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, T200, CD45, PTPRC, CD45
Tested Applications
Flow, IHC, IF
Physical Properties
Liquid
Curated Selection
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