IKKb Antibody [IKB355]
Product Specifications
Background
NF-kB is sequestered in the cytoplasm by IkBa, unable to translocate to the nucleus. IkB is part of the canonical pathway for NF-kB activation. IKKb is part of the IkB kinase complex, along with a second catalytic subunit, IKKa, and a regulatory subunit, IKKg. Along with IKKa, IKKb phosphorylates IkBa leading to its degradation and release of inhibition of NF-kB. The RELA subunit of active NF-kB is then free to enter the nucleus and initiate a number of signaling cascades.
NCBI Gene ID
3551
Swiss Prot
O14920
Host
Mouse
Reactivity
Human, Mouse
Immunogen
A recombinant protein fragment of IKKb was used as the immunogen for this antibody.
Clonality
Monoclonal
Clone
IKB355
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Inflammasomes
Purification
Protein G purified antibody
Concentration
0.5 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=33-004
Fragment
IgG1, kappa
Symbol
IKBKB
NCBI Official Name
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
NCBI Organism
Homo sapiens
Other Product Names
IKK beta Antibody: IKK2, IKKB, IMD15, NFKBIKB, IKK-beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, I-kappa-B-kinase beta
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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