Dnmt3b Antibody

Product Specifications

Background

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3b is a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.

NCBI Gene ID

1789

Swiss Prot

Q9UBC3

Accession Number

Q9UBC3

Host

Rabbit

Reactivity

Human

Immunogen

This Dnmt3b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-417 amino acids from human Dnmt3b.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

96 kDa

Fragment

Rabbit Ig

Symbol

DNMT3B

NCBI Official Name

DNA (cytosine-5) -methyltransferase 3B

NCBI Organism

Homo sapiens

Background Reference 01

Okano, M., et al., Cell 99 (3) :247-257 (1999) . Yin, B., et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 21 (6) :431-438 (1999) . Okano, M., et al., Nat. Genet. 19 (3) :219-220 (1998) .