Dnmt2 Antibody

Product Specifications

Background

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.

NCBI Gene ID

1787

Swiss Prot

O14717

Accession Number

O14717

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This Dnmt2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-375 amino acids from human Dnmt2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

45 kDa

Fragment

Rabbit Ig

Symbol

TRDMT1

NCBI Official Name

TRNA (cytosine (38) -C (5) ) -methyltransferase

NCBI Organism

Homo sapiens

Background Reference 01

Hermann, A., et al., J. Biol. Chem. 278 (34) :31717-31721 (2003) .

Background Reference 02

Franchina, M., et al., Int. J. Biochem. Cell Biol. 33 (11) :1104-1115 (2001) .

Background Reference 03

Dong, A., et al., Nucleic Acids Res. 29 (2) :439-448 (2001) .

Background Reference 04

Yoder, J.A., et al., Hum. Mol. Genet. 7 (2) :279-284 (1998) .

Other Product Names

TRNA (cytosine (38) -C (5) ) -methyltransferase, DNA (cytosine-5) -methyltransferase-like protein 2, Dnmt2, DNA methyltransferase homolog HsaIIP, DNA MTase homolog HsaIIP, MHsaIIP, PuMet, TRDMT1, DNMT2