GABBR2 Antibody

Product Specifications

Background

The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.

NCBI Gene ID

9568

Swiss Prot

O75899

Accession Number

O75899

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This GABBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 861-890 amino acids from the C-terminal region of human GABBR2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

106 kDa

Fragment

Rabbit Ig

Symbol

GABBR2

NCBI Official Name

Gamma-aminobutyric acid type B receptor subunit 2

NCBI Organism

Homo sapiens

Background Reference 01

Oblak, A.L., et al. J. Neurochem. 114 (5) :1414-1423 (2010)

Background Reference 02

Letra, A., et al. Am. J. Med. Genet.152A (7), 1701-1710 (2010) :

Background Reference 03

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 04

Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

Other Product Names

Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, HG20, GABBR2, GPR51, GPRC3B