BCAT1 Antibody

Product Specifications

Background

This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.

NCBI Gene ID

586

Swiss Prot

P54687

Accession Number

P54687

Host

Rabbit

Reactivity

Human

Immunogen

This BCAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-107 amino acids from the Central region of human BCAT1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

43 kDa

Fragment

Rabbit Ig

Symbol

BCAT1

NCBI Official Name

Branched-chain-amino-acid aminotransferase, cytosolic

NCBI Organism

Homo sapiens

Background Reference 01

Eijgelsheim, M., et al. Hum. Mol. Genet. 19 (19) :3885-3894 (2010)

Background Reference 02

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 03

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 04

Barber, M.J., et al. PLoS ONE (3), E9763 (2010) :

Other Product Names

Branched-chain-amino-acid aminotransferase, cytosolic, BCAT (c), Protein ECA39, BCAT1, BCT1, ECA39

Tested Applications

WB, IHC-P

Protein ID

215274162

Physical Properties

Liquid

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